ANTIOXIDANT, ENZYME INHIBITORY, and CYTOTOXIC ACTIVITY SCREENING of MYRTUS COMMUNIS L. MYRTUS COMMUNIS L.'NIN ANTIOKSIDAN, ENZIM INHIBITÖR VE SITOTOKSIK AKTIVITE TARAMALARI
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.47, sa.3, ss.827-835, 2023 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47 Sayı: 3
- Basım Tarihi: 2023
- Doi Numarası: 10.33483/jfpau.1264321
- Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.827-835
- Anahtar Kelimeler: Antioxidant, cytotoxic activity, enzyme inhibition, Myrtus communis
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Erciyes Üniversitesi Adresli: Evet
Özet
Objective: The present study aimed to evaluate the biological activities of Myrtus communis L., which has traditional medicinal use for different purposes, from a broad perspective. Material and Method: The antioxidant (DPPH, ABTS, total phenol, and flavonoid amounts) anti-inflammatory (LOX enzyme inhibition), antidiabetic (α-glucosidase enzyme inhibition), and cytotoxic properties (MTT assay) of a 70% methanol extract made from leaves and dichloromethane, butanol, ethyl acetate, and the residual water fractions were investigated. Result and Discussion: The DPPH radical scavenging effect of the ethyl acetate fraction, with the highest total phenol and flavonoid content, was found to be 1.4 ug/ml, and the ABTS radical scavenging effect was 2.58 mmol/Trolox. The most potent inhibitor of LOX (IC50: 31.17 ug/ml) and α-glucosidase (96% inhibition at 0.5 mg/ml) enzymes was determined as ethyl acetate extract. Dichloromethane fraction was shown to have the most cytotoxic activity in both Hela and Colo cell lines. This research has given us a better understanding of the traditional use of the M. communis plant, which stands out for its therapeutic properties.