Protective effect of L-carnitine against oxidative damage caused by experimental chronic aflatoxicosis in quail (Coturnix coturnix)
ACTA VETERINARIA HUNGARICA, cilt.53, sa.3, ss.319-324, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 53 Sayı: 3
- Basım Tarihi: 2005
- Doi Numarası: 10.1556/avet.53.2005.3.5
- Dergi Adı: ACTA VETERINARIA HUNGARICA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.319-324
- Anahtar Kelimeler: L-carnitine, malondialdehyde, reduced glutathione, aflatoxicosis, quail
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Erciyes Üniversitesi Adresli: Hayır
Özet
This study was designed to evaluate the effect of L-carnitine supplementation on the plasma malondialdehyde (MDA) and whole blood reduced glutathione (GSH) concentrations in experimentally-induced chronic aflatoxicosis in quails. For this purpose, a total of 80 quails up to 8 weeks old were divided into four equal groups. Group I served as control, Group 11 was given L-carnitine at the dose of 200 mg/litre in the drinking water for 60 days, Group III was given 60 mu g total aflatoxin/kg diet for 60 days, and Group IV was given both 60 mu g total aflatoxin/kg diet and 200 mg L-camitine/litre in the drinking water for 60 days. Aflatoxin treatment caused a significant increase in plasma MDA and a significant decrease in blood GSH concentrations. On the other hand, there was a significant decrease in plasma MDA and a significant increase in whole blood GSH in the L-carnitine-supplemented group. The present study demonstrated that L-carnitine brought about the inhibition of lipid peroxidation by enhancing antioxidant capacity in quails with chronic aflatoxicosis.