Protective effect of L-carnitine against oxidative damage caused by experimental chronic aflatoxicosis in quail (Coturnix coturnix)


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Citil M. , Gunes V. , Atakisi O., Ozcan A., Tuzcu M., Dogan A.

ACTA VETERINARIA HUNGARICA, cilt.53, sa.3, ss.319-324, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Konu: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1556/avet.53.2005.3.5
  • Dergi Adı: ACTA VETERINARIA HUNGARICA
  • Sayfa Sayıları: ss.319-324

Özet

This study was designed to evaluate the effect of L-carnitine supplementation on the plasma malondialdehyde (MDA) and whole blood reduced glutathione (GSH) concentrations in experimentally-induced chronic aflatoxicosis in quails. For this purpose, a total of 80 quails up to 8 weeks old were divided into four equal groups. Group I served as control, Group 11 was given L-carnitine at the dose of 200 mg/litre in the drinking water for 60 days, Group III was given 60 mu g total aflatoxin/kg diet for 60 days, and Group IV was given both 60 mu g total aflatoxin/kg diet and 200 mg L-camitine/litre in the drinking water for 60 days. Aflatoxin treatment caused a significant increase in plasma MDA and a significant decrease in blood GSH concentrations. On the other hand, there was a significant decrease in plasma MDA and a significant increase in whole blood GSH in the L-carnitine-supplemented group. The present study demonstrated that L-carnitine brought about the inhibition of lipid peroxidation by enhancing antioxidant capacity in quails with chronic aflatoxicosis.