Stereological Estimation of Brain Volume and Surface Area from MR Images

ACER N. , turgut m.

in: Neurostereology: Unbiased Stereology Of Neural Systems, Mouton PR, Editor, Wiley-Blackwell, Florida, pp.1-23, 2014

  • Publication Type: Book Chapter / Chapter Vocational Book
  • Publication Date: 2014
  • Publisher: Wiley-Blackwell
  • City: Florida
  • Page Numbers: pp.1-23
  • Editors: Mouton PR, Editor


MRI applied measurement of brain volume and surface area is presented and applied using stereological methods based on Cavalieri sections. The methods using point counting, vertical sectioning, isotropic Cavalieri, independent grid design and inavariator are described and worked different examples using stereological methods according to new literature. Also we discussed their variance and applicability.  Altough there are lots of studies which have focused on the volume estimation of brain using segmentation and stereological methods, there are a few studies on the measurement of the surface area of the brain using different methods in the literature. Volumetric analysis of brain and related structures using magnetic resonance imaging techniques may provide important information in certain neurological and neuropsychiatric disorders such as cortical atrophy, multiple sclerosis, Alzheimer’s disease, Parkinson’s disease and normal aging.