HISTOPATHOLOGY OF EXPERIMENTAL SPINAL-CORD TRAUMA - COMPARISON OF TREATMENT WITH TRH, NALOXONE, AND DEXAMETHASONE


AKDEMIR H. , PASAOGLU A. , OZTURK F. , SELCUKLU A. , KOC K., KURTSOY A.

RESEARCH IN EXPERIMENTAL MEDICINE, cilt.192, ss.177-183, 1992 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 192 Konu: 3
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1007/bf02576273
  • Dergi Adı: RESEARCH IN EXPERIMENTAL MEDICINE
  • Sayfa Sayısı: ss.177-183

Özet

The results of treatment with thyrotropin-releasing hormone (TRH), naloxone and dexamethasone treatments albino rats with experimental spinal cord injury were compared. All the animals were made paraplegic by the application clip method of Rivlin and Tator. Treatment was administered i.p. as bolus injections in two doses, at 45 and 120 min after the injury. Animals were allocated randomly to four experimental groups: (1) TRH (0.6 mg per dose), (2) naloxone (0.8 mg per dose), (3) dexamethasone (0.6 mg per dose), and (4) control (saline). TRH-treated rats showed significantly better histopathological scores than either naloxone or dexamethasone-treated ones (Kruskal Wallis: 24.058 P<0.001).