Bee bread shows therapeutic and protective effects by alleviating inflammation, oxidative stress, and apoptosis on acetic acid-induced gastric ulcer in rats

Çolak H., Sarıyer E. T., Yüksel M., Polat İ. Ö., Çikler E., Öner N., ...Daha Fazla

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, cilt.1, sa.1, ss.1-11, 2025 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1080/13813455.2025.2466191
  • Dergi Adı: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1-11
  • Erciyes Üniversitesi Adresli: Evet

Özet

ABSTRACTObjective: This study investigated bee bread’s (BB) protective and therapeutic effects on acetic acid-(AA)-induced gastric ulcers via oxidative stress, DNA damage, inflammation, and apoptosis.Materials and methods: Rats were administered saline-(1ml) or BB-(0.5g/kg/day;1ml) by oral gavageonce daily for 10-day following 80% AA-induced chronic ulceration in treatment group. Pretreatmentgroup received saline or BB for 10-day before and 3-day after ulcer induction. Stomachs of decapitatedrats were collected for ulcer index, histological and biochemical analyses.Results: BB significantly reduced the gastric ulcer index and levels of chemiluminescence, HMGB-1, IL-6,IL-1ß and IL-8 levels in pretreatment and treatment groups. In BB-pretreated ulcer group, MPO-(saline\BB, 39.9±3.7 U/g;22.2±2.2 U/g), caspase-3 (0.40±0.07 ng/g;0.18±0.01 ng/g) and IFN-γ (15.46±1.76;9.51±1.95ng/g) levels decreased and TNF-α (31.77±5.13;18.94±2.59 ng/g) reduced only in BB-treated ulcer group.MDA, GSH, NRF-2, and 8-OHdG levels remained unchanged.Conclusion: BB has demonstrated protective and therapeutic effects by reducing ROS production,modulating inflammation and apoptosis.