Ergothioneine pretreatment protects the liver from ischemia-reperfusion injury caused by increasing hepatic heat shock protein 70

BEDIRLI, Abdulkadir; SAKRAK, Ömer; Muhtaroglu, SABAHATTİN; Soyuer, Işın; Guler, I; ERDOGAN, AR; SOZUER, ERDOĞAN

doi:10.1016/j.jss.2004.06.016

Ergothioneine pretreatment protects the liver from ischemia-reperfusion injury caused by increasing hepatic heat shock protein 70

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BEDIRLI A., SAKRAK O., Muhtaroglu S., Soyuer I., Guler I., ERDOGAN A., ...More

JOURNAL OF SURGICAL RESEARCH, vol.122, no.1, pp.96-102, 2004 (SCI-Expanded)

Publication Type: Article / Article
Volume: 122 Issue: 1
Publication Date: 2004
Doi Number: 10.1016/j.jss.2004.06.016
Journal Name: JOURNAL OF SURGICAL RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.96-102
Keywords: liver, ischemia-reperfusion, ergothioneine, heat shock protein 70, OXIDATIVE DAMAGE, GENE-EXPRESSION, RAT-LIVER, IN-VIVO, APOPTOSIS, INDUCTION, TISSUES, CELL
Erciyes University Affiliated: Yes

Abstract

Background. Reperfusion of the liver after ischemia induces the expression of the heat shock genes and the synthesis of the heat shock proteins (HSP). We studied the effects of the natural antioxidant ergothioneine (EGT) treatment on the expression of HSP70 in ischemic-reperfused (IR) liver.