Fabrication Of Synthetic Fe@SiO2 Nanoparticles from Polystyrene Nanosphere Template and their Potential as Contrast Agents in MRI
International Nanoscience and Nanotechnology Conference, İstanbul, Türkiye, 26 - 28 Ağustos 2024, ss.237, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Basıldığı Şehir: İstanbul
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.237
- Erciyes Üniversitesi Adresli: Evet
Özet
Magnetic resonance imaging (MRI) is a common imaging technique utilized in medical settings due to its non-invasive nature and lack of ionizing radiation [1]. Nevertheless, the discrepancy in contrast between diseased and normal tissues upon exposure to a magnetic field is insufficient for the specific clinical diagnosis required and necessitates further research [2, 3]. To achieve meaningful differences in imaging, it is essential to enhance the relaxation properties of tissues. [3]. In this context, the use of contrast-enhancing materials is of paramount importance. In particular, the significant alterations observed in the production, functionalization, targeting, and surface modification of nanoparticles have made it imperative to investigate the utilization of nanoparticles as contrast agents. A review of the literature indicates that gadolinium (Gd+3) chelates and iron oxide-derived structures are particularly promising candidates for use as contrast agents [3]. Iron oxide nanoparticles (IONPs) represent the most extensively researched nanoparticles for contrast enhancement in T2-weighted imaging [4]. The advantageous properties of IONPs, including biocompatibility, high saturation magnetization, and reduction of T2 relaxation time, are frequently the subject of investigation [4]. The diverse characteristics of IONPs, including their crystal structure, chemical composition, size, and morphology, play a pivotal role in magnetic field manipulation [5]. Consequently, a polystyrene nanosphere (PNS) template was employed to fabricate oxidation-free, tunable nanoparticles in the form of nanobowls, with the objective of enhancing the interaction of IONPs with the magnetic field. PNSs were assembled on silicon wafers in a highly ordered manner, and their size was tuned to the desired extent by exposure to oxygen plasma via inductively-coupled plasma reactive ion etching (ICP-RIE). The technology is employed primarily for the patterning and masking of target surfaces. In this work, the field of application has been modified, and a novel approach for the synthesis of iron oxide nanoparticles (IONPs) without the use of chemical agents has been introduced. As a consequence, the enhanced magnetic properties, T2 enhancement capability, and low cellular cytotoxicity of IONPs produced by PNS template were demonstrated.