Hormonal changes in hemodialysis patients: Novel risk factors for mortality?

Gungor O., KOÇYİĞİT I., Carrero J. J. , YILMAZ M. I.

SEMINARS IN DIALYSIS, vol.30, no.5, pp.446-452, 2017 (SCI-Expanded) identifier

  • Publication Type: Article / Review
  • Volume: 30 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.1111/sdi.12611
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.446-452
  • Erciyes University Affiliated: Yes


Patients with end-stage renal disease undergoing dialysis commonly experience derangements in the hypothalamic-pituitary-gonadal axis together with alterations at the level of synthesis and clearance of many hormones. This hormonal imbalance, even if asymptomatic, has recently been associated with increased mortality in these patients. In this review, we summarize observational and mechanistic evidence linking hormonal alterations at the level of the thyroid and sex-hormone systems with this mortality risks.