Effect of some antidepressants on glycaemia and insulin levels of normoglycaemic and alloxan-induced hyperglycaemic mice

Erenmemisoglu A., Ozdogan U., Saraymen R., Tutus A.

JOURNAL OF PHARMACY AND PHARMACOLOGY, vol.51, no.6, pp.741-743, 1999 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 6
  • Publication Date: 1999
  • Doi Number: 10.1211/0022357991772899
  • Journal Name: JOURNAL OF PHARMACY AND PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.741-743
  • Erciyes University Affiliated: Yes

Abstract

Depression is an important problem among diabetic patients. We have investigated the effect of some antidepressant drugs on plasma glucose and insulin levels in normoglycaemic and alloxan-induced diabetic mice. For this purpose the effects of nortryptiline (as an example of a tricyclic antidepressant) and fluoxetine and sertraline (as examples of selective 5-HT re-uptake inhibitors) were examined on plasma glucose and insulin levels.