The treatment of insulin resistance does not improve adrenal cytochrome P450c17 alpha enzyme dysregulation in polycystic ovary syndrome


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Unluhizarci K. , Kelestimur F., Sahin Y. , Bayram F.

EUROPEAN JOURNAL OF ENDOCRINOLOGY, cilt.140, ss.56-61, 1999 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 140 Konu: 1
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1530/eje.0.1400056
  • Dergi Adı: EUROPEAN JOURNAL OF ENDOCRINOLOGY
  • Sayfa Sayısı: ss.56-61

Özet

Objective: To determine whether metformin, when given to non-diabetic women with polycystic ovary syndrome (PCOS), results in a reduction of insulin resistance and hyperinsulinemia while body weight is maintained. Also we aimed to see whether the reduction in insulin levels attenuates the activity of adrenal P450c17 alpha enzyme in patients with PCOS.