The role of TNF-alpha and PAI-1 gene polymorphisms in familial Mediterranean fever

DÜNDAR M. , Kiraz A. , Balta B. , Emirogullari E. F. , ZARARSIZ G. , Yurci A., et al.

MODERN RHEUMATOLOGY, cilt.23, ss.140-145, 2013 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 23 Konu: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s10165-012-0687-9
  • Sayfa Sayısı: ss.140-145


Familial Mediterranean fever (FMF) is one of the most serious inherited inflammatory disorders among Jewish, Armenian, Turkish and Arab populations. The imbalance between pro- and anti-inflammatory cytokines may play a role in its etiology. We have investigated whether tumor necrosis factor-alpha (TNF-alpha) and plasminogen activator inhibitor 1 (PAI-1) gene polymorphisms are associated with FMF and evaluated the relationship between these polymorphisms and genotypic manifestation of FMF.