The role of TNF-alpha and PAI-1 gene polymorphisms in familial Mediterranean fever
MODERN RHEUMATOLOGY, cilt.23, sa.1, ss.140-145, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 1
- Basım Tarihi: 2013
- Doi Numarası: 10.1007/s10165-012-0687-9
- Dergi Adı: MODERN RHEUMATOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.140-145
- Anahtar Kelimeler: Cytokine, Familial Mediterranean fever, PAI-1, Polymorphism, TNF-alpha
- Erciyes Üniversitesi Adresli: Evet
Özet
Familial Mediterranean fever (FMF) is one of the most serious inherited inflammatory disorders among Jewish, Armenian, Turkish and Arab populations. The imbalance between pro- and anti-inflammatory cytokines may play a role in its etiology. We have investigated whether tumor necrosis factor-alpha (TNF-alpha) and plasminogen activator inhibitor 1 (PAI-1) gene polymorphisms are associated with FMF and evaluated the relationship between these polymorphisms and genotypic manifestation of FMF.