The role of TNF-alpha and PAI-1 gene polymorphisms in familial Mediterranean fever

DÜNDAR M., Kiraz A., Balta B., Emirogullari E. F., ZARARSIZ G., Yurci A., ...Daha Fazla

MODERN RHEUMATOLOGY, cilt.23, sa.1, ss.140-145, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s10165-012-0687-9
  • Dergi Adı: MODERN RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.140-145
  • Anahtar Kelimeler: Cytokine, Familial Mediterranean fever, PAI-1, Polymorphism, TNF-alpha, NECROSIS-FACTOR-ALPHA, PLASMINOGEN-ACTIVATOR INHIBITOR-1, PROMOTER POLYMORPHISM, 4G/5G POLYMORPHISM, AMYLOIDOSIS, INTERLEUKIN-6, MUTATIONS, DISEASE, PROTEIN, PYRIN
  • Erciyes Üniversitesi Adresli: Evet

Özet

Familial Mediterranean fever (FMF) is one of the most serious inherited inflammatory disorders among Jewish, Armenian, Turkish and Arab populations. The imbalance between pro- and anti-inflammatory cytokines may play a role in its etiology. We have investigated whether tumor necrosis factor-alpha (TNF-alpha) and plasminogen activator inhibitor 1 (PAI-1) gene polymorphisms are associated with FMF and evaluated the relationship between these polymorphisms and genotypic manifestation of FMF.