DNA Cleavage Properties, Antimicrobial and Cytotoxic Activity and 4D-QSAR Analysis of Some Pyrazole Derivatives
LETTERS IN DRUG DESIGN & DISCOVERY, vol.16, pp.904-918, 2019 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 16
- Publication Date: 2019
- Doi Number: 10.2174/1570180815666180926104319
- Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.904-918
- Keywords: DNA cleavage, antimicrobial activity, cytotoxic activity, EC-GA method, 4D-QSAR, pyrazole
- Erciyes University Affiliated: Yes
Abstract
Background: An extensive study of 19 pyrazole derivatives were carried out based on the evaluation of DNA cleavage properties, antimicrobial and cytotoxic activities and 4D-QSAR analysis including pharmacophore modelling and bioactivity prediction by the Electron Conformational-Genetic Algorithm (EC-GA) method.