Atıf İçin Kopyala
Köprü S., Kup F. O., Sabanci N., Çadır M., Bulut D. C., Duman F., ...Daha Fazla
LETTERS IN DRUG DESIGN & DISCOVERY, cilt.16, ss.904-918, 2019 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
16
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Basım Tarihi:
2019
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Doi Numarası:
10.2174/1570180815666180926104319
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Dergi Adı:
LETTERS IN DRUG DESIGN & DISCOVERY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.904-918
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Anahtar Kelimeler:
DNA cleavage, antimicrobial activity, cytotoxic activity, EC-GA method, 4D-QSAR, pyrazole, ELECTRON-CONFORMATIONAL METHOD, PHARMACOPHORE IDENTIFICATION, BIOACTIVITY PREDICTION, ACID-CHLORIDES, BINDING, EVALUATE, 3D-QSAR, MODELS
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Erciyes Üniversitesi Adresli:
Evet
Özet
Background: An extensive study of 19 pyrazole derivatives were carried out based on the evaluation of DNA cleavage properties, antimicrobial and cytotoxic activities and 4D-QSAR analysis including pharmacophore modelling and bioactivity prediction by the Electron Conformational-Genetic Algorithm (EC-GA) method.