Rational Formation of Peptides Hybrid Nanoflower With Its Enzyme-Mimic and Antimicrobial Activities


Creative Commons License

Taşdemir D., Çelik Ç., Yusufbeyoğlu S., Ildız N. , Avan İ., Yılmaz V. , et al.

International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Ankara, Türkiye, 26 - 27 Nisan 2018, cilt.1, no.1, ss.273-279

  • Cilt numarası: 1
  • Basıldığı Şehir: Ankara
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayısı: ss.273-279

Özet

In this study, we develop, for the first time, the synthesis of novel peptide-inorganic hybrid nanoflowers (HNFs) formed of tripeptide as an organic component and copper (II) ion as an inorganic component in phosphate buffer saline (PBS) solution and to cast light on their peroxidase mimic and antimicrobial activities. The peptide used in the HNF was synthesized from three nonpolar and hydrophobic amino acids (glycine, leucine and phenylalanine). The presence of abundantly nonpolar R groups, Cu2+ ions and pores in the HNFs are relatively responsible in performing their peroxidase mimic activity by oxidation of guaiacol to colored 3,3-dimethoxy-4,4-diphenoquinone in the presence of hydrogen peroxide (H2O2) based on mechanism of Fenton-like reaction. The number of hydrophobic sites in the the HNFs and aforementioned factors above may play roles in denaturing bacterial cell membrane and lead to eventual cell death.