Akademik Veri Yönetim Sistemi
Taşdemir D., Çelik Ç., Yusufbeyoğlu S., Ildız N. , Avan İ., Yılmaz V. , et al.
International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Ankara, Türkiye, 26 - 27 Nisan 2018, cilt.1, no.1, ss.273-279
In this study, we develop, for the first time, the synthesis of novel peptide-inorganic hybrid
nanoflowers (HNFs) formed of tripeptide as an organic component and copper (II) ion as an
inorganic component in phosphate buffer saline (PBS) solution and to cast light on their
peroxidase mimic and antimicrobial activities. The peptide used in the HNF was synthesized
from three nonpolar and hydrophobic amino acids (glycine, leucine and phenylalanine). The
presence of abundantly nonpolar R groups, Cu2+ ions and pores in the HNFs are relatively
responsible in performing their peroxidase mimic activity by oxidation of guaiacol to colored
3,3-dimethoxy-4,4-diphenoquinone in the presence of hydrogen peroxide (H2O2) based on
mechanism of Fenton-like reaction. The number of hydrophobic sites in the the HNFs and
aforementioned factors above may play roles in denaturing bacterial cell membrane and lead to
eventual cell death.