The effects of deltamethrin on some serum biochemical parameters in mice

Eraslan G., Bilgili A., Essiz D., Akdogan M., Sahindokuyucu F.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, vol.87, no.2, pp.123-130, 2007 (SCI-Expanded) identifier


Sixty white male mice were used in this stud:. Three groups, each comprising 20 mice were established. The control group (Group 1) was provided ad libitum pellet feed. Oil the other hand, the experimental groups, namely, Groups 2 and 3 were given pellet feed containing deltamethrin throughout the day, so that the animals were administered doses of 7.5 and 30 mg/kg/body weight/day, respectively. Blood samples were collected from all groups on the 15th, 30th, 45th, and 60th days of the experiment for measurement of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alcaline phosphatase (ALP), amylase and cholinesterase activities, and levels of glucose, Urea, creatinine, triglyceride, cholesterol, calcium, phosphor, sodium, potassium, and chloride. According to data obtained, on the l5th day of the study, compared to the control group, statistically significant increase in urea, cholesterol, ALP, cholinesterase, calcium, and potassium levels/activities, and significant decrease in SGOT activity and chloride levels in Group 2, and significant increase in cholesterol, ALP, cholinesterase, calcium, potassium and chloride levels/activities in Group 3, and significant decrease in SGOT activity in Group 3 were determined. On the 30th day of the Study, in comparison to the control group, triglyceride and cholesterol levels and ALP activity were determined to be significantly increased in the Group 2, whereas SGOT activity were significantly reduced in Group 2, and triglyceride and cholesterol levels were demonstrated to be significantly increased and SGOT activity was significantly reduced in Group 3. On the 45th day of the study, compared to the controls, significant increase in cholesterol and sodium levels, and significant decrease in triglyceride levels and ALP activity in Group 2, significant increase in creatinine, cholesterol and sodium levels and cholinesterase activity, and significant decrease in glucose, SGPT, ALP and phosphor levels/activities were detected in Group 3. On the 60th day, in other words, in the last period of the study, ALP activity, and triglyceride, calcium, and phosphor levels were determined to be significantly increased and significant decrease in amylase activity in Group 2. Furthermore, significant increase in triglyceride, ALP, amylase, calcium, phosphor, and potassium levels/activities, and significant decrease in glucose and creatinine levels were observed in Group 3. However no correlation was determined to exist between the changes were found to be statistically significant, and the administration dose and duration of deltamethrin in all periods and groups. (c) 2006 Elsevier Inc. All rights reserved.