A molecular analysis of familial Mediterranean fever disease in a cohort of Turkish patients

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DÜNDAR M., Kiraz A., Emirogullari E. F., SAATÇİ Ç., Taheri S., BAŞKOL M., ...Daha Fazla

ANNALS OF SAUDI MEDICINE, cilt.32, sa.4, ss.343-348, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

Özet

BACKGROUND AND OBJECTIVES: Familial Mediterranean fever (FMF) is an autosomal recessive disorder caused by mutations in MEFV gene, which encodes pyrin. FMF is especially prevalent among Turks, Armenians, non-Ashkenazi Jews, and Arabs. The aim of this study was to determine the frequency and spectrum of 12 MEFV mutations of these patients and any genotype-phenotype correlation in this large Turkish group.