A molecular analysis of familial Mediterranean fever disease in a cohort of Turkish patients


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DÜNDAR M. , Kiraz A. , Emirogullari E. F. , SAATÇİ Ç. , Taheri S., BAŞKOL M. , et al.

ANNALS OF SAUDI MEDICINE, cilt.32, ss.343-348, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5144/0256-4947.2012.343
  • Dergi Adı: ANNALS OF SAUDI MEDICINE
  • Sayfa Sayısı: ss.343-348

Özet

BACKGROUND AND OBJECTIVES: Familial Mediterranean fever (FMF) is an autosomal recessive disorder caused by mutations in MEFV gene, which encodes pyrin. FMF is especially prevalent among Turks, Armenians, non-Ashkenazi Jews, and Arabs. The aim of this study was to determine the frequency and spectrum of 12 MEFV mutations of these patients and any genotype-phenotype correlation in this large Turkish group.