A molecular analysis of familial Mediterranean fever disease in a cohort of Turkish patients


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DÜNDAR M., Kiraz A., Emirogullari E. F., SAATÇİ Ç., Taheri S., BAŞKOL M., ...More

ANNALS OF SAUDI MEDICINE, vol.32, no.4, pp.343-348, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.5144/0256-4947.2012.343
  • Journal Name: ANNALS OF SAUDI MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.343-348
  • Erciyes University Affiliated: Yes

Abstract

BACKGROUND AND OBJECTIVES: Familial Mediterranean fever (FMF) is an autosomal recessive disorder caused by mutations in MEFV gene, which encodes pyrin. FMF is especially prevalent among Turks, Armenians, non-Ashkenazi Jews, and Arabs. The aim of this study was to determine the frequency and spectrum of 12 MEFV mutations of these patients and any genotype-phenotype correlation in this large Turkish group.