Platelet activation and inflammatory response in patients with non-dipper hypertension
ATHEROSCLEROSIS, cilt.209, sa.1, ss.278-282, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 209 Sayı: 1
- Basım Tarihi: 2010
- Doi Numarası: 10.1016/j.atherosclerosis.2009.09.010
- Dergi Adı: ATHEROSCLEROSIS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.278-282
- Anahtar Kelimeler: Mean platelet volume, C-reactive protein, Non-dipper hypertension, Platelet activation
- Erciyes Üniversitesi Adresli: Evet
Özet
Objective: Non-dipper hypertensives had about three times the risk of atherosclerotic events than hypertensives whose blood pressure was > 10% lower at night compared to daytime (dippers). Platelet activation and inflammatory response may derive from most atherosclerotic events. Mean platelet volume (MPV) is a determinant of platelet activation and high sensitive C-reactive protein (hs-CRP) is the best candidate assay to identify and monitor the inflammatory response. We aimed to determine whether MPV and hs-CRP levels are elevated in non-dipper patients compared to dippers and healthy controls. In addition, we tried to find out if MPV and CRP are related to each other or not in non-dipper hypertensives.