Platelet activation and inflammatory response in patients with non-dipper hypertension


Kaya M. G. , Yarlioglues M., Gunebakmaz O. , Gunturk E., Inanc T., DOĞAN A. , et al.

ATHEROSCLEROSIS, cilt.209, ss.278-282, 2010 (SCI İndekslerine Giren Dergi)

Özet

Objective: Non-dipper hypertensives had about three times the risk of atherosclerotic events than hypertensives whose blood pressure was > 10% lower at night compared to daytime (dippers). Platelet activation and inflammatory response may derive from most atherosclerotic events. Mean platelet volume (MPV) is a determinant of platelet activation and high sensitive C-reactive protein (hs-CRP) is the best candidate assay to identify and monitor the inflammatory response. We aimed to determine whether MPV and hs-CRP levels are elevated in non-dipper patients compared to dippers and healthy controls. In addition, we tried to find out if MPV and CRP are related to each other or not in non-dipper hypertensives.