Platelet activation and inflammatory response in patients with non-dipper hypertension

Kaya M. G., Yarlioglues M., Gunebakmaz O., Gunturk E., Inanc T., DOĞAN A., ...Daha Fazla

ATHEROSCLEROSIS, cilt.209, sa.1, ss.278-282, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 209 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.atherosclerosis.2009.09.010
  • Dergi Adı: ATHEROSCLEROSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.278-282
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objective: Non-dipper hypertensives had about three times the risk of atherosclerotic events than hypertensives whose blood pressure was > 10% lower at night compared to daytime (dippers). Platelet activation and inflammatory response may derive from most atherosclerotic events. Mean platelet volume (MPV) is a determinant of platelet activation and high sensitive C-reactive protein (hs-CRP) is the best candidate assay to identify and monitor the inflammatory response. We aimed to determine whether MPV and hs-CRP levels are elevated in non-dipper patients compared to dippers and healthy controls. In addition, we tried to find out if MPV and CRP are related to each other or not in non-dipper hypertensives.