Platelet activation and inflammatory response in patients with non-dipper hypertension


Kaya M. G., Yarlioglues M., Gunebakmaz O., Gunturk E., Inanc T., DOĞAN A., ...More

ATHEROSCLEROSIS, vol.209, no.1, pp.278-282, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 209 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1016/j.atherosclerosis.2009.09.010
  • Journal Name: ATHEROSCLEROSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.278-282
  • Erciyes University Affiliated: Yes

Abstract

Objective: Non-dipper hypertensives had about three times the risk of atherosclerotic events than hypertensives whose blood pressure was > 10% lower at night compared to daytime (dippers). Platelet activation and inflammatory response may derive from most atherosclerotic events. Mean platelet volume (MPV) is a determinant of platelet activation and high sensitive C-reactive protein (hs-CRP) is the best candidate assay to identify and monitor the inflammatory response. We aimed to determine whether MPV and hs-CRP levels are elevated in non-dipper patients compared to dippers and healthy controls. In addition, we tried to find out if MPV and CRP are related to each other or not in non-dipper hypertensives.