BIOLOGICAL ACTIVITY EVALUATION OF NOVEL N-HETEROCYCLIC CARBENE PRECURSORS


AKKOÇ S. , GÖK Y., Erdogan H., ALBAYRAK S.

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, cilt.8, ss.262-267, 2017 (ESCI İndekslerine Giren Dergi)

  • Cilt numarası: 8 Konu: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.13040/ijpsr.0975-8232.8(1).262-67
  • Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
  • Sayfa Sayısı: ss.262-267

Özet

Five novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors (1a-e). They were characterized by different techniques. The antimicrobial activities of these compounds were tested. The compounds showed moderate activity against three Gram (+) and seven Gram (-) bacteria in comparison to tetracycline, which was used as the standard antibiotic, whereas all the compounds (1a-e) showed no activity against the test yeast C. albicans.