Effects of Amrinone in an Experimental Model of Hepatic Ischemia-Reperfusion Injury

Küçük C., AKCAN A., Akyyldyz H. Y., AKGÜN H., Muhtaroglu S., Sozuer E.

JOURNAL OF SURGICAL RESEARCH, cilt.151, sa.1, ss.74-79, 2009 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 151 Sayı: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.jss.2008.02.008
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.74-79
  • Anahtar Kelimeler: ischemia-reperfusion injury, liver, phosphodiesterase inhibitors, amrinone, TUMOR-NECROSIS-FACTOR, CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES, ORTHOTOPIC LIVER-TRANSPLANTATION, PORTOSYSTEMIC SHUNT, ADENOSINE-MONOPHOSPHATE, PROSTAGLANDIN E-1, PROTECTS LIVER, WARM ISCHEMIA, CELL INJURY, RAT-LIVER
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background. During some surgical interventions, temporary occlusion of the hepatic blood supply may cause ischemia-reperfusion (IR) injury. Recent studies suggest that type 3 phosphodiesterase inhibitors may have a beneficial effect on liver IR injury. The aim of this study was to investigate whether amrinone, a type 3 phosphodiesterase inhibitor, could have a protective effect on liver having experimental liver IR injury.