Effects of Amrinone in an Experimental Model of Hepatic Ischemia-Reperfusion Injury

Küçük C., AKCAN A., Akyyldyz H. Y. , AKGÜN H. , Muhtaroglu S., Sozuer E.

JOURNAL OF SURGICAL RESEARCH, vol.151, no.1, pp.74-79, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 151 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1016/j.jss.2008.02.008
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.74-79
  • Keywords: ischemia-reperfusion injury, liver, phosphodiesterase inhibitors, amrinone, TUMOR-NECROSIS-FACTOR, CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES, ORTHOTOPIC LIVER-TRANSPLANTATION, PORTOSYSTEMIC SHUNT, ADENOSINE-MONOPHOSPHATE, PROSTAGLANDIN E-1, PROTECTS LIVER, WARM ISCHEMIA, CELL INJURY, RAT-LIVER

Abstract

Background. During some surgical interventions, temporary occlusion of the hepatic blood supply may cause ischemia-reperfusion (IR) injury. Recent studies suggest that type 3 phosphodiesterase inhibitors may have a beneficial effect on liver IR injury. The aim of this study was to investigate whether amrinone, a type 3 phosphodiesterase inhibitor, could have a protective effect on liver having experimental liver IR injury.