Umbilical cord N-terminal procollagen of type l collagen (P1NP) and beta C-terminal telopeptide (βCTX) levels in term pregnancies with vitamin D deficiency

Sahin M. E., ŞAHİN E., MADENDAĞ Y., Madendag I. C., Karakukcu Ç., AÇMAZ G.

Gynecological Endocrinology, cilt.37, sa.3, ss.211-215, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/09513590.2020.1830967
  • Dergi Adı: Gynecological Endocrinology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.211-215
  • Erciyes Üniversitesi Adresli: Evet

Özet

© 2020 Informa UK Limited, trading as Taylor & Francis Group.Aims: The aim of the present study was to evaluate umbilical cord N-terminal procollagen of type l collagen (P1NP) and beta C-terminal telopeptide (βCTX) levels in term pregnancies with vitamin D deficiency. Materials and methods: Ninety-two pregnant women between 19 and 35-years-old who delivered at term gestational age were included in the study and divided into deficient (n = 32), insufficient (n = 30), and normal (control) vitamin D levels (n = 30). Results: Maternal demographic characteristics and biochemical parameters were similar among groups. The mean umbilical cord P1NP level was 221.4 (211.7–231.0, 95%CI) pg/mL in the vitamin D deficiency group, 282.5 (271.2–293.8, 95%CI) pg/mL in the vitamin D insufficiency group, and 280.9 (270.9–290.8, 95%CI) pg/mL in the control group and significantly lower in vitamin D deficiency group than others (p <.001). Umbilical cord P1NP level was similar in the vitamin D insufficiency group and control group (p =.971). The mean umbilical cord βCTX level was 5530, 9 (5511.5–5550.3, 95%CI) pg/mL in the vitamin D deficiency group, 5516.3 (5498.4–5534.2, 95%CI) pg/mL in the vitamin D insufficiency group, and 5510 (5491.4–5528.5, 95%CI) pg/mL in the control group, which was statistically similar among the groups (p =.251). Conclusion: Our results indicated that vitamin D deficiency during pregnancy affects fetal bone osteoblast activity.