A comparison of low-dose ACTH, glucagon stimulation and insulin tolerance test in patients with pituitary disorders

Simsek Y., Karaca Z. C., TANRIVERDİ F., ÜNLÜHİZARCI K., SELÇUKLU A., Kelestimur F.

CLINICAL ENDOCRINOLOGY, cilt.82, sa.1, ss.45-52, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 82 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/cen.12528
  • Dergi Adı: CLINICAL ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.45-52
  • Erciyes Üniversitesi Adresli: Evet

Özet

ContextDiagnosis of secondary adrenal insufficiency and GH deficiency requires evaluation by dynamic stimulation tests in most cases. Although insulin tolerance test (ITT) is accepted as the gold-standard test for the evaluation of both hypothalamo-pituitary-adrenal (HPA) and (GH)-IGF-1 axes, the test is cumbersome. In clinical practice, low-dose adrenocorticotrophic hormone (ACTH) stimulation test is a sensitive, safe and easily applicable alternative to ITT. Although it takes more time, glucagon stimulation test (GST) is also a good alternative to ITT and can evaluate both axes.