Treatment with Met-RANTES decreases bacterial translocation in experimental colitis

KUCUK C., SOZUER E. M., GURSOY S., CANOZ O., ARTIS T., AKCAN A. C., ...More

AMERICAN JOURNAL OF SURGERY, vol.191, no.1, pp.77-83, 2006 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 191 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1016/j.amjsurg.2005.10.005
  • Journal Name: AMERICAN JOURNAL OF SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.77-83
  • Keywords: bacterial translocation, colitis, cytokine, experimental, RANTES, MESENTERIC LYMPH-NODES, ULCERATIVE-COLITIS, CROHNS-DISEASE, CHEMOTACTIC CYTOKINES, CHEMOKINES, INFLAMMATION, MODEL, ENDOTOXEMIA, PROGRESSION, EXPRESSION
  • Erciyes University Affiliated: Yes

Abstract

Background: During colitis, epithelial function is impaired, leading to increased bacterial translocation. Recent studies have shown the important role of proinflammatory cytokines and chemokines, including RANTES (regulated on activation. normal T-cell expressed and secreted), in inflammatory bowel diseases (IBDs). In this study, we evaluated the role of Met-RANTES, an antagonist of the RANTES receptor, on the impairment of bacterial translocation in a rat model of colitis.