Treatment with Met-RANTES decreases bacterial translocation in experimental colitis

KUCUK, C; SOZUER, ERDOĞAN; GURSOY, ŞEBNEM; CANOZ, ÖZLEM; ARTIS, T; AKCAN, Alper; AKYILDIZ, HIZIR; Muhtaroglu, SABAHATTİN

doi:10.1016/j.amjsurg.2005.10.005

Treatment with Met-RANTES decreases bacterial translocation in experimental colitis

KUCUK C., SOZUER E. M., GURSOY S., CANOZ O., ARTIS T., AKCAN A. C., ...Daha Fazla

AMERICAN JOURNAL OF SURGERY, cilt.191, sa.1, ss.77-83, 2006 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 191 Sayı: 1
Basım Tarihi: 2006
Doi Numarası: 10.1016/j.amjsurg.2005.10.005
Dergi Adı: AMERICAN JOURNAL OF SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.77-83
Anahtar Kelimeler: bacterial translocation, colitis, cytokine, experimental, RANTES, MESENTERIC LYMPH-NODES, ULCERATIVE-COLITIS, CROHNS-DISEASE, CHEMOTACTIC CYTOKINES, CHEMOKINES, INFLAMMATION, MODEL, ENDOTOXEMIA, PROGRESSION, EXPRESSION
Erciyes Üniversitesi Adresli: Evet

Özet

Background: During colitis, epithelial function is impaired, leading to increased bacterial translocation. Recent studies have shown the important role of proinflammatory cytokines and chemokines, including RANTES (regulated on activation. normal T-cell expressed and secreted), in inflammatory bowel diseases (IBDs). In this study, we evaluated the role of Met-RANTES, an antagonist of the RANTES receptor, on the impairment of bacterial translocation in a rat model of colitis.