The number and activity of CD3(+)TCR V alpha 7.2(+)CD161(+) cells are increased in children with acute rheumatic fever
INTERNATIONAL JOURNAL OF CARDIOLOGY, vol.333, pp.174-183, 2021 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 333
- Publication Date: 2021
- Doi Number: 10.1016/j.ijcard.2021.02.020
- Journal Name: INTERNATIONAL JOURNAL OF CARDIOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Public Affairs Index, Veterinary Science Database
- Page Numbers: pp.174-183
- Keywords: Acute rheumatic fever, ARF, Mucosal-associated invariant cell, MAIT
- Erciyes University Affiliated: Yes
Abstract
Background: Acute rheumatic fever (ARF) is an autoimmune disease caused by group A beta-hemolytic streptococci (GAS) and may develop into rheumatic heart disease (RHD). The pathogenesis of ARF and RHD involves molecular mimicry and antibody-mediated mechanisms. T cell involvement is described in various stages of the disease. Mucosal associated invariant T (MATT) cells are enriched at the mucosa and are present in the blood and may be activated by GAS.