Human genome-microbiome interaction: metagenomics frontiers for the aetiopathology of autoimmune diseases

GÜNDOĞDU A., Nalbantoglu U.

MICROBIAL GENOMICS, cilt.3, sa.4, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 3 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1099/mgen.0.000112
  • Dergi Adı: MICROBIAL GENOMICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: genome-microbiome interaction, metagenomics, autoimmune disease, HUMAN GUT MICROBIOME, WIDE ASSOCIATION, HERITABILITY, CATALOG, GWAS
  • Erciyes Üniversitesi Adresli: Evet

Özet

A short while ago, the human genome and microbiome were analysed simultaneously for the first time as a multi-omic approach. The analyses of heterogeneous population cohorts showed that microbiome components were associated with human genome variations. In-depth analysis of these results reveals that the majority of those relationships are between immune pathways and autoimmune disease-associated microbiome components. Thus, it can be hypothesized that autoimmunity may be associated with homeostatic disequilibrium of the human-microbiome interactome. Further analysis of human genome-human microbiome relationships in disease contexts with tailored systems biology approaches may yield insights into disease pathogenesis and prognosis.