Iodine-mediated oxidative N-S bond formation: a facile one-pot synthetic approach to 1,2,4-benzothiadiazine 1,1-dioxides under transition metal-free conditions

Buran Uğur S., Doğan Ş. D.

JOURNAL OF SULFUR CHEMISTRY, vol.44, no.3, pp.354-360, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.1080/17415993.2022.2164693
  • Journal Name: JOURNAL OF SULFUR CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica
  • Page Numbers: pp.354-360
  • Keywords: 1, 2, 4-benzothiadiazine 1, 1-dioxide, iodine, one-pot synthesis, oxone, urea
  • Erciyes University Affiliated: Yes

Abstract

Benzothiadiazine 1,1-dioxide derivatives are widely used because of their diverse biological activities and medicinal prospects. In this study, iodine-oxone mediated oxidative N-S bond formation reaction was described. This new and transition-metal-free approach allows for the convenient synthesis of a variety of 1,2,4-benzothiadiazine 1,1-dioxides from readily available urea derivatives under very mild conditions without using expensive reagents and catalysts. Further, this protocol allows for the development of a library of key building blocks with potential medical applications.