Iodine-mediated oxidative N-S bond formation: a facile one-pot synthetic approach to 1,2,4-benzothiadiazine 1,1-dioxides under transition metal-free conditions

Buran Uğur S., Doğan Ş. D.

JOURNAL OF SULFUR CHEMISTRY, cilt.44, sa.3, ss.354-360, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/17415993.2022.2164693
  • Dergi Adı: JOURNAL OF SULFUR CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica
  • Sayfa Sayıları: ss.354-360
  • Anahtar Kelimeler: 1,2,4-benzothiadiazine 1,1-dioxide, iodine, one-pot synthesis, oxone, urea
  • Erciyes Üniversitesi Adresli: Evet

Özet

Benzothiadiazine 1,1-dioxide derivatives are widely used because of their diverse biological activities and medicinal prospects. In this study, iodine-oxone mediated oxidative N-S bond formation reaction was described. This new and transition-metal-free approach allows for the convenient synthesis of a variety of 1,2,4-benzothiadiazine 1,1-dioxides from readily available urea derivatives under very mild conditions without using expensive reagents and catalysts. Further, this protocol allows for the development of a library of key building blocks with potential medical applications.