Akademik Veri Yönetim Sistemi
AÇBID-AsianAOMS Joint Congress - AÇBİD 16th International Congress, Antalya, Türkiye, 10 - 14 Mayıs 2023, cilt.17, ss.60-61, (Özet Bildiri)
Objective: Osteoporosis is a progressive metabolic bone disease characterized by deterioration of bone microarchitecture. Success of hard tissue augmentation in the alveolar crest is significally reduced in patients with osteoporosis. Recent studies show that, probiotics stop or slow down osteoporosis-induced bone destruction. Its effects on bone are to decrease osteoclastic activity or increase osteoblastic activity, depending on the type of probiotic. The purpose of this study is to determine the effect of probiotics on bone formation in subjects with or without osteoporosis whom undergone maxillary sinus floor elevation surgery. Materials-Methods: Twenty four female New Zealand rabbits were randomly divided four groups with six rabbits each and bilateral MSFA was performed in each animal. Group 1 (G1); Control group Group 2 (G2); Given probiotics without osteoporosis, Group 3 (G3); Osteoporotic, not given probiotics, Group 4 (G4); Osteoporotic, given probiotics. 1 mg/kg methylprednisolone was administered intramuscularly every day for 6 weeks, starting approximately 2 weeks after the operation. Samples were examined 8 weeks after MSFE surgery with micro-CT and histologically. Results: Bone Mineral Density was higher in the 2nd group compared to other groups. The difference between all parameters except Bone Volume (BV), Bone Volume over Total Volume (BV/ TV) were significant between the 2nd and 3rd groups in the micro-CT measurements (p<0.05). Micro-CT and histological examinations in both groups were quite similar. Conclusion: The quality of the bone formed with maxillary sinus floor elevation surgery was observed to be similar to the control group in osteoporotic patients supplemented with probiotics. Keywords: Maxillary Sinus, Osteoporosis, Probiotics