The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro


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Demiroglu-Zergeroglu A., Basara-Cigerim B., KILIÇ E. , YANIKKAYA-DEMIREL G.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Basım Tarihi: 2010
  • Doi Numarası: 10.1155/2010/851589
  • Dergi Adı: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Özet

Malignant Mesothelioma (MM) is an aggressive and lethal tumour of the serosal surfaces with poor prognosis. In this study, we have investigated the antiproliferative effect of Quercetin (QU) and its combination with Cisplatin (CIS) on SPC212 and SPC111 cell lines. Our experiments showed that QU significantly reduced the proliferation of cell lines, altered the cell cycle distribution, and increased the level of Caspase 9 (C9) and Caspase 3 (C3) in concentration and time-dependent manner. Additionally, the combination of QU + CIS was found more e. ective when compared with individual treatment of agents.