Anthrax is still an endemic disease in central parts of the world including Turkey. The aim of this study was to assess the local therapeutic options by reviewing the articles published in Turkey about the antibiotic susceptibility of Bacillus anthracis. A total of 138 clinical isolates from human cases were evaluated in 5 studies from 1990 to 2007. All isolates tested against penicillin G were susceptible. None of the strains produced beta-lactamase. Doxcycline, tetracycline, erythromycin, aminoglycosides and ciprofloxacin were highly active against all strains. According to the results of this analysis, penicillin G is still a reliable option for the treatment of naturally acquired human anthrax in Turkey.