Could imiquimod (Aldara 5% cream) or other TLR7 agonists be used in the treatment of COVID-19?

AVCILAR H., Eken A.

MEDICAL HYPOTHESES, cilt.144, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 144
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.mehy.2020.110202
  • Dergi Adı: MEDICAL HYPOTHESES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Imiquimod, TLR7, SARS CoV-2, COVID-19, INTERFERON, RESPONSES
  • Erciyes Üniversitesi Adresli: Evet

Özet

Toll-like receptor 7 is critical in recognition of single strand RNA viruses, including SARS CoV-2, and generation of anti-viral immunity. Coronaviruses evolved strategies to dampen the host immunity. Herein, we discuss the potential use of TLR7 agonists in the early stages of COVID-19 treatment.