In this study the effect of the trace mineral, boron (B) was determined on the potassium dichromate induced oxidative damage in the brain tissue of Sprague Dawley rats. Malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) enzymes were estimated in the brain tissues of the Sprague Dawley rats. Compared to the control groups, a significant increase in the brain tissue MDA level of the group which received only 10 mg/kg K2Cr2O7 was observed, whereas no statistically significant change was detected in SOD, CAT and GSH-Px enzyme activities. It was further observed that after administration of Boron at 5 and 10 mg/kg the lipid peroxidation in brain tissue of K2Cr2O7 -treated rats decreased significantly, but no significant changes were observed in the levels of antioxidant enzyme. It can be concluded that administration of 5 and 10 mg/ kg B may have beneficial effects against lipid peroxidation caused by K2Cr2O7 in the brain tissue of rats.