Exploring Genetic Factors Associated with Moniezia spp. Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach

Arzik Y., Kizilaslan M., Behrem S., Piel L. M. W., White S. N., ÇINAR M. U.

Animals, vol.15, no.6, 2025 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 6
  • Publication Date: 2025
  • Doi Number: 10.3390/ani15060812
  • Journal Name: Animals
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: parasite resistance, <italic>Ovis aries</italic>, genome-wide association, <italic>Moniezia</italic> spp., <italic>CD79A</italic> gene
  • Erciyes University Affiliated: Yes

Abstract

Gastrointestinal parasite (GIP) infections are a major challenge in pasture-based sheep farming, leading to both economic losses and animal welfare concerns. This study aimed to identify genetic factors that contribute to resistance against tapeworm (Moniezia spp.) infections in Central Anatolian Merino (CAM) sheep. We conducted genome-wide association studies (GWAS) on 226 CAM lambs, analyzing their genetic data in relation to Moniezia spp. egg burden. Thirteen significant genetic markers (SNPs) were identified. Two key immune-related genes, CD79A and MAP3K7, were linked to parasite resistance. CD79A is essential for B-cell activation and antibody production, while MAP3K7 regulates immune responses, particularly through NF-κB signaling. These findings highlight the potential for using genetic information to improve disease resistance in livestock breeding programs. Further research is needed to understand the role of these genes and to explore host–parasite interactions in more detail.