Evaluation of the effect of intranasal infiltrated botulinum toxin-A on a model of allergic rhinitis in rabbits: An Experimental Study


Gunes M. S. , Kulahli I., Kokoglu K. , VURAL A. , Avci D. , Gulec S. , ...More

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, vol.83, no.4, pp.51-56, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1016/j.ijporl.2016.01.010
  • Title of Journal : INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
  • Page Numbers: pp.51-56
  • Keywords: Acetylcholine, Eosinophils, Immunotherapy, Turbinates, Metaplasia, FREY-SYNDROME, NASAL-MUCOSA, INJECTION, ASTHMA, MEDICINE, SYMPTOMS, UPDATE, IMPACT, RATS

Abstract

Introduction: Allergic Rhinitis (AR) effects 20-40% of the global population and its prevalance increases. Medical treatment and immunotherapy could be used in AR management. But they are not definitive solution. Medical treatment must be used a long time and has side effects. Immunotherapy cannot be applied to every patient and it also takes a long time. The aim of this study is to evaluate symptomatic and histopathological effects of intranasal infiltrated Botulinum Toxin-A (Btx-A) on an animal model of AR.