The effects of metformin on insulin resistance and ovarian steroidogenesis in women with polycystic ovary syndrome


Unluhizarci K. , Kelestimur F., Bayram F. , Sahin Y. , Tutus A.

CLINICAL ENDOCRINOLOGY, cilt.51, ss.231-236, 1999 (SCI İndekslerine Giren Dergi)

Özet

OBJECTIVE Polycystic ovary syndrome (PCOS) is a form of functional ovarian hyperandrogenism and affects approximately 5-10% of women of reproductive age, Insulin resistance and hyperinsulinaemia appear to be almost universal feature of the polycystic ovary syndrome. Abnormal regulation of cytochrome P450c17 alpha causes the exaggerated secretion of ovarian androgens in PCOS, The aim of the present study was to determine whether reduction of insulin levels by metformin would attenuate FSH, LH, 17-Hydroxyprogesterone (17-OHP) and androstenedione hyperresponsiveness to buserelin testing in PCOS women.