Evaluation of the rs35996865 polymorphism of the ROCK1 gene in sepsis

KALE A., ŞENER E. F., Gunay N. E., Tahtasakal R., DEMİRYÜREK Ş., GÜNAY N., ...More

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, vol.68, no.5, pp.586-590, 2022 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.1590/1806-9282.20211105
  • Journal Name: REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.586-590
  • Keywords: ROCK-I protein kinase, Single nucleotide polymorphism, Mortality, Sepsis
  • Erciyes University Affiliated: Yes

Abstract

OBJECTIVE: Sepsis is a complex and serious medical condition resulting from the activation of an innate host response to infections. The etiology of sepsis is complex and can be influenced by genetic susceptibility. The purpose of the present study was to investigate a possible association of Rhokinase 1 (ROCK1) gene polymorphism with sepsis in a Turkish population.