From paramutation to human disease: RNA-mediated heredity


Rassoulzadegan M. , Cuzin F.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, vol.44, pp.47-50, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 44
  • Publication Date: 2015
  • Doi Number: 10.1016/j.semcdb.2015.08.007
  • Title of Journal : SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
  • Page Numbers: pp.47-50

Abstract

Epigenetic variation, a stable alteration in gene expression, occurs at multiple moments during development. Several instances of non-Mendelian transmission to the progenies modes are very intriguing. Studies of the mode of hereditary transmission revealed in a series of such cases a role of noncoding RNA molecules as inducers. While still an enigmatic mechanism, emerging models pinpoint to a more general roles of these variations, initiated as a response to genetic and environmental variation. Here we compare the known modes of transgenerational epigenetic variation in mice and humans. (C) 2015 Elsevier Ltd. All rights reserved.