From paramutation to human disease: RNA-mediated heredity
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, cilt.44, ss.47-50, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 44
- Basım Tarihi: 2015
- Doi Numarası: 10.1016/j.semcdb.2015.08.007
- Dergi Adı: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.47-50
- Erciyes Üniversitesi Adresli: Evet
Özet
Epigenetic variation, a stable alteration in gene expression, occurs at multiple moments during development. Several instances of non-Mendelian transmission to the progenies modes are very intriguing. Studies of the mode of hereditary transmission revealed in a series of such cases a role of noncoding RNA molecules as inducers. While still an enigmatic mechanism, emerging models pinpoint to a more general roles of these variations, initiated as a response to genetic and environmental variation. Here we compare the known modes of transgenerational epigenetic variation in mice and humans. (C) 2015 Elsevier Ltd. All rights reserved.