Unusual effects of GH deficiency in adults: a review about the effects of GH on skin, sleep, and coagulation

TANRIVERDİ F., Karaca Z., ÜNLÜHİZARCI K., Kelestimur F.

ENDOCRINE, cilt.47, sa.3, ss.679-689, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 47 Sayı: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/s12020-014-0276-0
  • Dergi Adı: ENDOCRINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.679-689
  • Anahtar Kelimeler: GH deficiency, GH replacement, Skin, Sweating, Sleep, Coagulation, Fibrinolysis, Pituitary, Hemostasis, GROWTH-HORMONE DEFICIENCY, PLASMINOGEN-ACTIVATOR INHIBITOR, CARDIOVASCULAR RISK-FACTORS, TRAUMATIC BRAIN-INJURY, REPLACEMENT THERAPY, INCREASED PREVALENCE, ENDOTHELIAL DYSFUNCTION, FIBRINOLYTIC MARKERS, HYPOPITUITARY ADULTS, ADHESION MOLECULES
  • Erciyes Üniversitesi Adresli: Evet

Özet

Based on the literature data in the last two decades, growth hormone deficiency (GHD) in adults has been accepted as a clinical entity. Due to the presence of GH and IGF-I receptors throughout the body, the physiological effects of the GH-IGF-I axis are still under investigation. The effects of GH on skin, sleep, and coagulation parameters in adults have only been investigated in detail only in the recent years. In this review, our aim was to summarize the literature regarding the effects of GHD and GH replacement treatment on the skin, sleep, and coagulation parameters in adults.