Angiotensin-Converting Enzyme Inhibitors Induce Cough


YILMAZ İ.

Turkish Thoracic Journal, vol.20, no.1, pp.36-42, 2019 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 20 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.5152/turkthoracj.2018.18014
  • Title of Journal : Turkish Thoracic Journal
  • Page Numbers: pp.36-42
  • Keywords: Cough, angiotensin converting enzyme inhibitors, hypertension, ACE-INHIBITORS, BRONCHIAL HYPERREACTIVITY, DIAGNOSTIC EVALUATION, GENE POLYMORPHISM, ADVERSE-REACTIONS, KEY COMPONENTS, BLOOD-PRESSURE, RECEPTOR GENE, CAPTOPRIL, HYPERTENSION

Abstract

Angiotensin-converting enzyme inhibitors (ACE-I) are widely used in diseases, such as hypertension, congestive heart failure, and myocardial infarction. Although these drugs are well tolerated, one out of five patients discontinues ACE-I due to drug side effects, mainly chronic cough. However, the pathogenesis of ACE-I-induced cough remains controversial and requires further study. In this review, the mechanisms that are suggested in ACE-I-induced cough pathophysiology will be discussed in detail in light of the current literature.