Angiotensin-Converting Enzyme Inhibitors Induce Cough

YILMAZ İ.

Turkish Thoracic Journal, cilt.20, sa.1, ss.36-42, 2019 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 20 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5152/turkthoracj.2018.18014
  • Dergi Adı: Turkish Thoracic Journal
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.36-42
  • Anahtar Kelimeler: Cough, angiotensin converting enzyme inhibitors, hypertension, ACE-INHIBITORS, BRONCHIAL HYPERREACTIVITY, DIAGNOSTIC EVALUATION, GENE POLYMORPHISM, ADVERSE-REACTIONS, KEY COMPONENTS, RECEPTOR GENE, CAPTOPRIL, HYPERTENSION, SENSITIVITY
  • Erciyes Üniversitesi Adresli: Evet

Özet

Angiotensin-converting enzyme inhibitors (ACE-I) are widely used in diseases, such as hypertension, congestive heart failure, and myocardial infarction. Although these drugs are well tolerated, one out of five patients discontinues ACE-I due to drug side effects, mainly chronic cough. However, the pathogenesis of ACE-I-induced cough remains controversial and requires further study. In this review, the mechanisms that are suggested in ACE-I-induced cough pathophysiology will be discussed in detail in light of the current literature.