Natural product-based nanoformulations for cancer therapy: Opportunities and challenges.


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Kashyap D., Tuli H., Yerer M. B., Sharma A., Sak K., Srivastava S., ...More

Seminars in cancer biology, vol.69, pp.5-23, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69
  • Publication Date: 2021
  • Doi Number: 10.1016/j.semcancer.2019.08.014
  • Journal Name: Seminars in cancer biology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.5-23
  • Keywords: Natural product, Nanoformulation, Cancer, Therapeutic, Anticancer, Synergistic effect, OVERCOME MULTIDRUG-RESISTANCE, POLYMER HYBRID NANOPARTICLES, LOADED GELATIN NANOPARTICLES, ENHANCED ANTITUMOR EFFICACY, CARCINOMA IN-VITRO, CO-DELIVERY, DRUG-DELIVERY, GAMBOGIC ACID, PLGA NANOPARTICLES, URSOLIC ACID
  • Erciyes University Affiliated: Yes

Abstract

Application of natural product-based nanoformulations for the treatment of different human diseases, such as cancer, is an emerging field. The conventional cancer therapeutic modalities, including surgery, chemotherapy, immunotherapy, radiotherapy has limited achievements. A larger number of drawbacks are associated with these therapies, including damage to proliferating healthy tissues, structural deformities, systemic toxicity, long-term side effects, resistance to the drug by tumor cells, and psychological problems. The advent of nanotechnology in cancer therapeutics is recent; however, it has progressed and transformed the field of cancer treatment at a rapid rate. Nanotherapeutics have promisingly overcome the limitations of conventional drug delivery system, i.e., low aqueous solubility, low bioavailability, multidrug resistance, and non-specificity. Specifically, natural product-based nanoformulations are being intentionally studied in different model systems. Where it is found that these nanoformulations has more proximity and reduced side effects. The nanoparticles can specifically target tumor cells, enhancing the specificity and efficacy of cancer therapeutic modalities which in turn improves patient response and survival. The integration of phytotherapy and nanotechnology in the clinical setting may improve pharmacological response and better clinical outcome of patients.