Synthesis of Copper Hybrid Nanoflowers Incorporating Alkanna cappadocica Boiss. Et. Bal. Root Extract: Antileishmanial, Antioxidant, and Peroxidase-Like Activities


Yusufbeyoglu S., YÜRÜK M., ÖÇSOY İ., BALDEMİR KILIÇ A.

ChemistrySelect, cilt.11, sa.2, 2026 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 2
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1002/slct.202502863
  • Dergi Adı: ChemistrySelect
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
  • Anahtar Kelimeler: Alkanna cappadocica, Copper nanoflower, Green synthesis, Leishmania tropica, Peroxidase-like activity
  • Erciyes Üniversitesi Adresli: Evet

Özet

In this study, organic–inorganic hybrid copper nanoflowers (NFs) were synthesized for the first time using Cu2+ ions as the inorganic component and Alkanna cappadocica root extracts as the organic component. The morphology of the NFs was characterized by field emission scanning electron microscopy (FE-SEM), while functional groups and crystal structures were analyzed using Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). The phenolic and flavonoid contents of the NFs were lower than those of the extracts; however, theyp exhibited significant peroxidase-like catalytic activity absent in the extracts. Antioxidant activity was assessed using DPPH and ABTS assays, with IC50 values ranging from 22.7 to 580 µg/mL. Antileishmanial studies revealed concentration-dependent effects, inducing distinct morphological changes in parasites, with IC50 values between 189.5 and 571 µg/mL. These findings demonstrate a green synthesis approach for copper-based hybrid NFs with promising catalytic, antioxidant, and antileishmanial properties, suggesting their potential as novel biomedical and antiparasitic agents.