Brain volume differences in Huntington disease using MRI
Erciyes Medical Genetics Days, Kayseri, Türkiye, 21 - 23 Şubat 2019, ss.4, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Doi Numarası: 10.14744/etd.2019.55631-
- Basıldığı Şehir: Kayseri
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.4
- Erciyes Üniversitesi Adresli: Evet
Özet
Huntington’s disease (HD) is an autosomal dominant degener ative disease that results from an expanded CAG repeat in the IT15 gene. Recent neuroimaging advances have contributed to the improved definition of brain regions where neural alter ations occur in patients with HD. Early research on HD focused on volumetric changes in brain gray matter (GM), mostly in volving the basal ganglia and cortex. We enrolled 4 gene-posi tive subjects for the study. VolBrain was used for data analysis of all structural T1-weighted images. Brain tissues were segmented with a fully automated with Volbrain. For this MRI study, to tal intracranial volume and GM, WM, and cerebrospinal fluid (CSF) volume were calculated. The total brain volumes and total cortical grey and white matter volume of the HD patients were reduced by compared with matched controls