Effect of interleukin-10 on tissue damage caused by organophosphate poisoning


Yurumez Y. , Ikizceli I. , Sozuer E. M. , Soyuer I. , Yavuz Y. , Avsarogullari L., et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, cilt.100, ss.323-327, 2007 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 100 Konu: 5
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1742-7843.2007.00049.x
  • Dergi Adı: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
  • Sayfa Sayısı: ss.323-327

Özet

Organophosphate poisoning is a common cause of severe morbidity and mortality among patients admitted to emergency departments. Tissue damages as a consequence of organophosphate poisoning are frequently reported, but preventing this potentially severe complication has not been the subject of much research. We tested whether interleukin-10, a cytoprotective agent, could prevent or diminish pathological signs of tissue damages caused by organophosphate poisoning. Thirty rats were divided into three equal groups (n = 10). Group I (sham) did not receive any agent during the experiment. Group 2 (control) received 0.8 g/kg of fenthion intraperitoneally, followed by 6 ml/kg of intraperitoneal normal saline 30 min. and 3 hr later. Group 3 (treatment) received 0.8 g/kg of fenthion intraperitoneally, followed by 2 mu g/kg of interleukin- 10 intraperitoneally 30 min. and 3 hr later. All rats were killed under anaesthesia after 6 hr and tissue samples were obtained from liver, kidneys and lungs. Even organophosphate poisonings do not cause significant clinical problems; several degrees of damages could be observed in liver, kidneys and lungs. These damages could be reduced by interleukin-10 treatment.