Metformin improves endothelial function and carotid intima media thickness in patients with PCOS


KAYA M. G. , YILDIRIM S. , ÇALAPKORUR B. , AKPEK M. , ÜNLÜHİZARCI K. , Kelestimur F.

GYNECOLOGICAL ENDOCRINOLOGY, vol.31, no.5, pp.401-405, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.3109/09513590.2015.1006188
  • Title of Journal : GYNECOLOGICAL ENDOCRINOLOGY
  • Page Numbers: pp.401-405

Abstract

Objective: Oral contraceptive pills (OCP) are widely used for treating women with polycystic ovary syndrome (PCOS). Metformin has beneficial effects on insulin resistance and endothelial functions. The aim of this study was to investigate the effects of treatment with drospirenone/ethinyl estradiol (EE) alone or in combination with metformin on the flow-mediated vasodilatation (FMD) and carotid intima media thickness (CIMT) in women with PCOS.