Metformin improves endothelial function and carotid intima media thickness in patients with PCOS

KAYA M. G., YILDIRIM S., ÇALAPKORUR B., AKPEK M., ÜNLÜHİZARCI K., Kelestimur F.

GYNECOLOGICAL ENDOCRINOLOGY, cilt.31, sa.5, ss.401-405, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/09513590.2015.1006188
  • Dergi Adı: GYNECOLOGICAL ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.401-405
  • Anahtar Kelimeler: Carotid intima media thickness, flow-mediated vasodilatation, metformin, oral contraceptive pills, polycystic ovary syndrome, POLYCYSTIC-OVARY-SYNDROME, CARDIOVASCULAR RISK, INSULIN-RESISTANCE, ELASTIC PROPERTIES, NONOBESE WOMEN, ANDROGEN, DISEASE, AORTA
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objective: Oral contraceptive pills (OCP) are widely used for treating women with polycystic ovary syndrome (PCOS). Metformin has beneficial effects on insulin resistance and endothelial functions. The aim of this study was to investigate the effects of treatment with drospirenone/ethinyl estradiol (EE) alone or in combination with metformin on the flow-mediated vasodilatation (FMD) and carotid intima media thickness (CIMT) in women with PCOS.