Metformin improves endothelial function and carotid intima media thickness in patients with PCOS

KAYA M. G., YILDIRIM S., ÇALAPKORUR B., AKPEK M., ÜNLÜHİZARCI K., Kelestimur F.

GYNECOLOGICAL ENDOCRINOLOGY, vol.31, no.5, pp.401-405, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.3109/09513590.2015.1006188
  • Journal Name: GYNECOLOGICAL ENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.401-405
  • Keywords: Carotid intima media thickness, flow-mediated vasodilatation, metformin, oral contraceptive pills, polycystic ovary syndrome, POLYCYSTIC-OVARY-SYNDROME, CARDIOVASCULAR RISK, INSULIN-RESISTANCE, ELASTIC PROPERTIES, NONOBESE WOMEN, ANDROGEN, DISEASE, AORTA
  • Erciyes University Affiliated: Yes

Abstract

Objective: Oral contraceptive pills (OCP) are widely used for treating women with polycystic ovary syndrome (PCOS). Metformin has beneficial effects on insulin resistance and endothelial functions. The aim of this study was to investigate the effects of treatment with drospirenone/ethinyl estradiol (EE) alone or in combination with metformin on the flow-mediated vasodilatation (FMD) and carotid intima media thickness (CIMT) in women with PCOS.