Selenium partially prevents cisplatin-induced neurotoxicity: A preliminary study

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Erken H. A., Koc E. R., Yazici H., Yay A. H., Önder G. Ö., Sarici S. F.

NEUROTOXICOLOGY, vol.42, pp.71-75, 2014 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 42
  • Publication Date: 2014
  • Doi Number: 10.1016/j.neuro.2014.04.002
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.71-75
  • Erciyes University Affiliated: Yes


Cisplatin is an anticancer drug and it has neurotoxic effects. On the other hand, the neuroprotective effect

of selenium was observed in previous studies. However, the effect of selenium on cisplatin-induced

neurotoxicity has not been studied yet. Therefore, we aimed to investigate whether selenium prevent

cisplatin-induced neurotoxicity. Twenty-one male Wistar albino rats were divided into three groups:

control (C), cisplatin (CS), cisplatin and selenium (CSE, n = 7 in each group). Cisplatin (12 mg/kg/day, i.p.)

was administered for 3 days to CS and CSE groups. Also, CSE group received via oral gavage 3 mg/kg/day

(twice-a-day as 1.5 mg/kg) selenium 5 days before of cisplatin injection and continued for 11

consecutive days. The same volumes of saline were intraperitoneally and orally administered to C group

at same time. At the end of experimental protocol, electrophysiological and histopathological

examinations were performed. The nerve conduction velocity, amplitude of compound action potential

and number of axon of CS group were signi?cantly lower than the C group. However, the same

parameters of CSE group were signi?cantly higher than the CS group. Although, cisplatin has a peripheral

neurotoxic effect in rats, this effect was partially prevented by selenium treatment. Thus, it appears that

co-administration of selenium and cisplatin may be a useful approach to decrease severity of peripheral