Akademik Veri Yönetim Sistemi
NEUROTOXICOLOGY, cilt.42, ss.71-75, 2014 (SCI-Expanded)
Cisplatin is an anticancer drug and it has neurotoxic effects. On the other hand, the neuroprotective effect
of selenium was observed in previous studies. However, the effect of selenium on cisplatin-induced
neurotoxicity has not been studied yet. Therefore, we aimed to investigate whether selenium prevent
cisplatin-induced neurotoxicity. Twenty-one male Wistar albino rats were divided into three groups:
control (C), cisplatin (CS), cisplatin and selenium (CSE, n = 7 in each group). Cisplatin (12 mg/kg/day, i.p.)
was administered for 3 days to CS and CSE groups. Also, CSE group received via oral gavage 3 mg/kg/day
(twice-a-day as 1.5 mg/kg) selenium 5 days before of cisplatin injection and continued for 11
consecutive days. The same volumes of saline were intraperitoneally and orally administered to C group
at same time. At the end of experimental protocol, electrophysiological and histopathological
examinations were performed. The nerve conduction velocity, amplitude of compound action potential
and number of axon of CS group were signi?cantly lower than the C group. However, the same
parameters of CSE group were signi?cantly higher than the CS group. Although, cisplatin has a peripheral
neurotoxic effect in rats, this effect was partially prevented by selenium treatment. Thus, it appears that
co-administration of selenium and cisplatin may be a useful approach to decrease severity of peripheral
neurotoxicity.