Research Information System
Journal of Electroanalytical Chemistry, vol.986, 2025 (SCI-Expanded)
The precise detection of antiretroviral agents, such as Dolutegravir (DTG), is essential for effective HIV treatment and optimal patient management. This study presents the synthesis of NiSe2/Mo-MOF nanocomposite and its application as a modifier for the accurate detection of DTG in pharmaceutical formulations and biological fluids. NiSe₂ nanocrystals were synthesized using a modified hydrothermal method and subsequently incorporated into a Mo-MOF matrix through a solvothermal process. Characterization of the nanocomposite was performed using X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and electrochemical impedance spectroscopy (EIS). Electrochemical investigations demonstrated that the NiSe₂/Mo-MOF sensor exhibited excellent sensitivity, selectivity, and reproducibility, with a low detection limit of 3.68 nM for DTG. The superior performance of the sensor can be attributed to the synergistic interaction between NiSe₂ and Mo-MOF. This study demonstrates the potential of NiSe₂/Mo-MOF nanocomposites as efficient, reliable, and cost-effective electrochemical sensors, providing a promising platform for drug monitoring in clinical and pharmaceutical applications.