NOR expression increases on metaphase chromosomes of Down syndrome lymphocytes in concordance with mitogen concentration in culture medium


Imamoglu N. N. , Demirtas H., Donmez-Altuntas H. , Hamurcu Z., Ilten A.

CYTOMETRY PART B-CLINICAL CYTOMETRY, no.1, pp.36-39, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1002/cyto.b.20050
  • Title of Journal : CYTOMETRY PART B-CLINICAL CYTOMETRY
  • Page Numbers: pp.36-39
  • Keywords: trisomy 21, metaphase nucleolus organizer regions, SYNDROME BRAIN, RIBOSOMAL GENES, PROTEIN-LEVELS, REDUCTION, NUCLEOLI, REGIONS, AGNOR

Abstract

Background: Regulation of nucleolus organizer region (NOR) expression in trisomy 21 (Down syndrome [DS] cells is not fully explained. This work compared NOR expression on metaphase chromosomes in gradiently stimulated lymphocytes from DS patients with those from healthy controls.