Anti-aging formulation of rosmarinic acid-loaded ethosomes and liposomes

Yücel Ç., Karatoprak G., Değim İ. T.

JOURNAL OF MICROENCAPSULATION, cilt.36, sa.2, ss.180-191, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/02652048.2019.1617363
  • Dergi Adı: JOURNAL OF MICROENCAPSULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.180-191
  • Anahtar Kelimeler: Rosmarinic acid, ethosome, liposome, skin penetration, antioxidant activity, anticollagenase, antielastase activity, OXIDATIVE DNA-DAMAGE, ANTIOXIDANT, DELIVERY, SKIN, OFFICINALIS, DRUGS
  • Erciyes Üniversitesi Adresli: Evet

Özet

The study was aimed to evaluate the effectiveness of rosmarinic acid (RA) loaded ethosomes (ETHs) and liposomes (LPs) when subjected to the transdermal application. RA-loaded ETHs and LPs were prepared, optimised, and characterised. The ex vivo permeation studies of formulations using mouse abdominal skin were performed. Antioxidant activities and the inhibitory effects of formulations on collagenase and elastase enzymes were measured. Optimised ethosomal formulation (F3) was showed nanometric size range (138 +/- 1.11 nm) and greatest entrapment (55 +/- 1.80%), was selected for further transdermal permeation studies. Skin permeation profile of the nanoformulations analysed by HPLC revealed an enhanced permeation of ETHs. Transdermal flux of ETHs was found to be higher than RA solution and LPs. Enzyme inhibitions of ETHs were the significant difference found between ETHs and LPs (p < 0.05). ETHs were found to be more effective and successful than LPs. Results suggest that ETHs are more effective than LPs for transdermal delivery of RA.