Microwave-assisted synthesis and myorelaxant activity of 9-indolyl-1,8-acridinedione derivatives

GÜNDÜZ, MİYASE; Isli, Fatma; El-Khouly, Ahmed; Yildirim, Seniz; Fincan, Gokce; ŞİMŞEK, RAHİME; Safak, Cihat; Sarioglu, Yusuf; Yildrim, SEMA; Butcher, Ray

doi:10.1016/j.ejmech.2014.01.059

Microwave-assisted synthesis and myorelaxant activity of 9-indolyl-1,8-acridinedione derivatives

GÜNDÜZ M. G., Isli F., El-Khouly A., Yildirim S., Fincan G. S. O., ŞİMŞEK R., ...Daha Fazla

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.75, ss.258-266, 2014 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 75
Basım Tarihi: 2014
Doi Numarası: 10.1016/j.ejmech.2014.01.059
Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.258-266
Anahtar Kelimeler: Acridinedione, Myorelaxant activity, Potassium channel, Pinacidil
Erciyes Üniversitesi Adresli: Evet

Özet

In this study a microwave-assisted method was applied for the synthesis of novel 9-(substituted indolyl)-3,4,6,7-tetrahydroacridine-1,8-(2H,5H,9H,10H)-dione derivatives. The structures of the compounds were confirmed by spectral methods including X-ray studies and elemental analysis.