Chromosomal and oxidative DNA damage in non-functioning pituitary adenomas.


Bitgen N. , Bayram F., Hamurcu Z., Ozturk F., Simsek Y., Baskol G., ...More

Endokrynologia Polska, vol.72, pp.97-103, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72
  • Publication Date: 2021
  • Doi Number: 10.5603/ep.a2020.0084
  • Title of Journal : Endokrynologia Polska
  • Page Numbers: pp.97-103

Abstract

Introduction: Clinically non-functioning pituitary adenomas (NFPA) are common tumours of the pituitary gland and are mainly considered as benign. The primary aim of this study was to research the effects of NFPA on genome instability in patients with non-functioning pituitary adenoma by using the cytokinesis-block micronucleus cytome (CBMN-cyt) assay and 8-hydroxy-2'-deoxyguanosine (8-OHdG) assay. The second objective of this study was to assess whether there is a relationship between age, pituitary adenoma diameters, 8-OHdG levels, CBMN site assay parameters, and tumour aggressiveness.