Prognostic value of total thiol and D-dimer in patients hospitalized with COVID-19

Keti D. B., Muhtaroglu S., Yildiz O., Saraçoglu H.

TURKISH JOURNAL OF BIOCHEMISTRY, cilt.48, sa.2, ss.209-214, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1515/tjb-2022-0171
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.209-214
  • Anahtar Kelimeler: COVID-19, D-dimer, ischemia-modified albumin, prognosis, thiol
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objectives: The lack of specific treatment for COVID-19 and the fact that the clinical course differs between individuals makes it difficult to predict the prognosis. The aim was to investigate the prognostic value of total thiol, D-dimer, procalcitonin (PCT), ischemia-modified albumin (IMA), and complete blood count (CBC) in patients hospitalized with COVID-19.

Methods: 100 consecutive patients were hospitalized with COVID-19, confirmed by RT-PCR between December 2021-March 2022 and 30 healthy control participated in the study. According to the World Health Organization guideline, two groups were created as critical and noncritical. D-dimer, PCT, IMA, total thiol levels, and CBCwere analyzed. Receiver-operating characteristic curves (ROC) were utilized to determine an optimum cut-off value for distinction.

Results: We defined a cut-off value of 1,030 μg/L for D-dimer (Area Under Curve, AUC): 0.691; p=0.001) and 148 μmol/L for total thiol (AUC: 0.749; p<0.001) via ROC analysis. The combination of D-dimer and total thiol reached 65% positive predictive value (PPV) and 80% negative predictive value (NPV).

Conclusions: D-dimer and total thiol may help predict critical patients with COVID-19.