Objective: This study was performed to investigate the effects of chromium picolinate (CrPic) supplementation on body composition, and blood chemistry related to carbohydrate, lipid, protein and mineral metabolisms in obese women. Materials and methods: Observed were 12 women, between 17-50 years of age, with body mass index (BMI, kg/m2) over 25 received 200 μg/day of chromium as CrPic for 8 weeks. Basal metabolic rate (BMR), anthropometric and selected biochemical parameters as well as serum insulin, leptin and ghrelin were measured at baseline and 8 weeks. Results: Chromium picolinate reduced waist and hip circumferences (p < 0.01) but had no effect on the other anthropometric measurements and BMR. A slight but not significant decrease was found in fasting blood glucose. Plasma leptin (p < 0.001) levels of the subjects decreased. No statistically significant differences were determined in insulin, ghrelin and in the other biochemical parameters. Conclusion: The results of this study have shown that 200 μg/day of chromium as CrPic for 8 weeks reduced leptin levels and waist and hip circumferences and, thus, abdominal obesity. ©2006 Dustri-Verlag Dr. K. Feistle.