A case that developed acute generalized exanthematous pustulosis after hydroxychloroquine use and did not follow the ordinary healing process despite drug discontinuation Hidroksiklorokin kullanımından sonra akut generalize ekzantematöz püstüloz gelişen ve ilaç kesilmesine rağmen olağan iyileşme sürecini takip etmeyen bir olgu

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KIZILTEPE M., OĞUZ KÖKOĞLU E., Eldemir Y. Ö., Şaş S., ŞENEL A. S.

Journal of Turkish Society For Rheumatology, vol.15, no.3, pp.171-174, 2023 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.4274/raed.galenos.2023.46855
  • Journal Name: Journal of Turkish Society For Rheumatology
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.171-174
  • Keywords: Acute generalized exanthematous pustulosis, case report, hydroxychloroquine, methotrexate
  • Erciyes University Affiliated: Yes

Abstract

Acute generalized exanthematous pustulosis is a disease that usually presents with sudden onset and widespread rash over the body. It is a condition characterized by non-follicular, sterile pustules that develop acutely with a base of edematous erythema. Acute generalized exanthematous pustulosis is usually drug-related, and hydroxychloroquine, an antimalarial drug frequently used in rheumatology practice, is one of the rare causes of acute generalized exanthematous pustulosis. Generally, spontaneous regression is expected after drug discontinuation. A sixty-year-old female patient developed acute generalized exanthematous pustulosis while receiving hydroxychloroquine. Despite drug discontinuation and steroid treatment, the lesions were persistent. The patient was treated with methotrexate and the lesions had resolved. It is aimed to raise awareness of the rare hydroxychloroquine-acute generalized exanthematous pustulosis relationship and its treatment with methotrexate by presenting this case.